Description
Product Characteristics:
Aliases: Deubiquinating enzyme A antibody, Deubiquitinating enzyme A antibody, DKFZp761A052 antibody, DUBA antibody, MGC104871 antibody, OTTHUMP00000025821 antibody, OTU domain containing 5 antibody, OTU domain containing protein 5 antibody, OTU domain-containing protein 5 antibody, OTUD 5 antibody, otud5 antibody, OTUD5_HUMAN antibody
Target Information: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]